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In contrast large proportionsneed oxygen at day 28 and for at least 28 days duringtheir hospitalization.

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Ten of these patients (10 of 11, 90.9%) had arelapse-free survival, and 7 of 11 (63.6%) had an infection-free survival of ?2 years. The first to beintroduced was chlortetracycline in 1948 under the nameaureomycin (because of the golden yellow colour of S.aureofaciens colonies producing it). The differentialarrangement of various types of sensory andmotor fibres in a mixed nerve may partly accountfor the differential blockade

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Freshly fractured silica has beenshown to cause DnA strand breaks in a cellular system, whichis blocked by catalase and •Oh scavengers (dimethylsulfoxideor sodium benzoate) indicating a role for ROS in this damage.Transcription factors, including nF-?B and AP-1, are associ-ated with lung injury by being involved with silica-inducedROS production in alveolar macrophages and epidermal cells.In addition, cellular, animal, and human data indicate that silicaexposure also stimulates nO production in the lung.

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